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. 2018 Jul 26;14:1917–1936. doi: 10.3762/bjoc.14.166

Table 5.

Conventional path for the synthesis of different intermediates based on approach 1.

intermediate multistep synthesis flow path

prexasertib monolactate monohydrate P1+P2→HE1→TR1→E1→TR2→TR3→RE1→T2→TR4→F1→T1
aliskiren hemifumatate P1+P2→R1→S1→S2→TR4→S1→PBC→C1→S2→T2
diphenhydramine hydrochloride P1+P2→R1→H1→BPR→CH→S1
lidocaine hydrochloride P1+P2→R1→R2→BPR→CH→S1
diazepam P1+P2→R1→R2→BPR→CH→S1
fluoxetine hydrochloride P1+P2→R1→R2→S1→S2→R3→S1→H1→R2→T1
ricociclib P1+P2→R1→R2→S1→R4→T1
rolipram P1+P2→PBR1→X→TR1→PBR2→PBR3→Y→Z→T3