Table 5.

Conventional path for the synthesis of different intermediates based on approach 1.

intermediate	multistep synthesis flow path
prexasertib monolactate monohydrate	P1+P2→HE1→TR1→E1→TR2→TR3→RE1→T2→TR4→F1→T1
aliskiren hemifumatate	P1+P2→R1→S1→S2→TR4→S1→PBC→C1→S2→T2
diphenhydramine hydrochloride	P1+P2→R1→H1→BPR→CH→S1
lidocaine hydrochloride	P1+P2→R1→R2→BPR→CH→S1
diazepam	P1+P2→R1→R2→BPR→CH→S1
fluoxetine hydrochloride	P1+P2→R1→R2→S1→S2→R3→S1→H1→R2→T1
ricociclib	P1+P2→R1→R2→S1→R4→T1
rolipram	P1+P2→PBR1→X→TR1→PBR2→PBR3→Y→Z→T3