Table 2. Minimum inhibitory concentrations for S. aureus (ATCC 43300) at 48 h for co-polymers, PVP, 5 and DFP in RPMI.
| Co-polymer | Content of 5 in polymer a (mol%) | MIC |
||
| μg mL–1 | μM b | μMFe c | ||
| a | 9.5 | 8 | 0.21 | 0.07 |
| b | 15.3 | 4 | 0.13 | 0.04 |
| c | 25.6 | 2 | 0.15 | 0.05 |
| PVP | 0 | 256 000 | 25 600 | N/A |
| 5 | N/A | 125 | 530 | 176 |
| DFP | N/A | 40 | 288 | 96 |
aMeasured using 1H NMR spectroscopy (see ESI).
bMolarity expressed as equivalent concentration of 5 based on the mol% of 5 in each polymer.
cMIC value normalized for maximum amount of iron bound by each chelator, assuming octahedral coordination with the following (ligand : Fe) ratios: co-polymer (3 : 1), 5 (3 : 1), DFP (3 : 1). The ratio for co-polymers is expressed according to the tris-chelate complexes of 5.