Table 2. Type of inhibition mechanism, as well as KI and KIS values of 5a, 5g and 6a.
Comp. | Inhibition mechanism | K I value (μM) | K IS value (μM) |
5a | Non-competitive type | 3.8 | 3.8 |
5g | Mixed type | 10.0 | 35.6 |
6a | Mixed type | 8.0 | 72.2 |
Comp. | Inhibition mechanism | K I value (μM) | K IS value (μM) |
5a | Non-competitive type | 3.8 | 3.8 |
5g | Mixed type | 10.0 | 35.6 |
6a | Mixed type | 8.0 | 72.2 |