Table 10. Cytotoxicity of the metal complexes 3.35–3.43 and cisplatin following exposure to the ovarian carcinoma cells A2780 and A2780cisR (cisplatin-resistant) for 72 h.
Complex | R3 | Ligand | IC50 (μM) |
|
A2780 | A2780cisR | |||
3.35 | cym | 3.31 | 7.6 ± 1.3 | 61 ± 5 |
3.36 | benz | 3.31 | 16.7 ± 1.2 | 13 ± 1 |
3.37 | hmb | 3.31 | 63.1 ± 1.2 | 442 ± 20 |
3.38 | cym | 3.32 | 96 ± 4 | 243 ± 19 |
3.39 | benz | 3.33 | 23 ± 2 | 20 ± 1 |
3.40 | hmb | 3.33 | 20 ± 1 | 21 ± 4 |
3.41 | cym | 3.33 | 20 ± 1 | 24 ± 3 |
3.42 | benz | 3.34 | 31 ± 2 | 30 ± 10 |
3.43 | cym | 3.34 | 126 ± 14 | 49 ± 1 |
Cisplatin | 1.0 ± 0.2 | 25 ± 1 |