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. 2017 Dec 6;9(3):409–436. doi: 10.1039/c7md00526a

Table 10. Cytotoxicity of the metal complexes 3.353.43 and cisplatin following exposure to the ovarian carcinoma cells A2780 and A2780cisR (cisplatin-resistant) for 72 h.

Complex R3 Ligand IC50 (μM)
A2780 A2780cisR
3.35 cym 3.31 7.6 ± 1.3 61 ± 5
3.36 benz 3.31 16.7 ± 1.2 13 ± 1
3.37 hmb 3.31 63.1 ± 1.2 442 ± 20
3.38 cym 3.32 96 ± 4 243 ± 19
3.39 benz 3.33 23 ± 2 20 ± 1
3.40 hmb 3.33 20 ± 1 21 ± 4
3.41 cym 3.33 20 ± 1 24 ± 3
3.42 benz 3.34 31 ± 2 30 ± 10
3.43 cym 3.34 126 ± 14 49 ± 1
Cisplatin 1.0 ± 0.2 25 ± 1