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| Compound | R 1 | R 2 | Nek4 IC50 nM | Nek4 % Inh | COT IC50 (nM) |
| Abbott Cmpd 17 |
|
|
50 | — | 1120 |
| Genentech Cmpd 1 |
|
|
— | 47.5 a | 410 |
| Genentech Cmpd 2 |
|
|
— | 89.9 a | 150 |
| Genentech Cmpd 32 |
|
|
— | 8.7 b | — |
| Abbott Cmpd 3359 |
|
|
316 | — | — |
| Abbott Cmpd 3357 |
|
|
1000 | — | — |
a100 nM screening concentration.
b1 μM screening concentration.
