Table 8. Selectivity profiles of JNK inhibitors across the Nek family.

Compound	JNK-IN-1 a	JNK-IN-2 b	JNK-IN-7 a	JNK-IN-8 a	JNK-9L c	JNK-IN-11 a	JNK-IN-12 a
	% control (10 μM)
Nek1	100	63	77	81	57	100	100
Nek2	100	1.1	86	100	94	93	99
Nek3	99	17	6.8	73	0.8	99	100
Nek4	100	100	83	79	100	100	100
Nek5	51	2.2	7.8	92	1.4	98	100
Nek6	44	2.8	17	100	76	100	100
Nek7	20	9.8	7	100	45	100	100
Nek9	100	22	48	100	63	100	63
Nek11	78	100	86	99	100	100	100
# kinases ≤10% control	26	45	35	14	53	63	9

^a Data taken from Zhang et al., 2012.

^b HMS LINCS Dataset 20048.

^c HMS LINCS Dataset 20078.