Table 9. BAY 61-3606 and structural analogues with reported Nek1 and Nek4 activity values.
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Compound | BAY 61-3606 | BAY derivative 1 | BAY derivative 6 | BAY derivative 8 | BAY derivative 21 | BAY derivative 28 |
nM | % Inhibition (1 μM) |
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NEK1 | 159 | 8 | 9 | 9 | 9 | 11 |
NEK4 | 25 | 7 | 15 | 13 | 13 | 7 |