Figure 6.

External exposure space using the preliminary benchmark dose giving rise to a 15% cognitive deficit (${\text{BMD}}_{15\text{CD}}$) and lower limit benchmark dose giving rise to a 15% cognitive deficit (${\text{BMDL}}_{15\text{CD}}$) for rats. Boundaries for the ${\text{BMD}}_{15}$ and ${\text{BMDL}}_{15}$ were derived from Equation 4 when the external exposure scenario gives rise to a CPF brain concentration at the proposed ${\text{BMD}}_{15}$ and ${\text{BMDL}}_{15}$ in the rat. Fraction of day exposed (FOD) represents how much of the day a rat is exposed to the total applied dose (TAD). Red (square hatching), orange (no hatching), and green (diagonal hatching) shading indicate exposure scenarios that fall above the ${\text{BMD}}_{15\text{CD}}$, between the ${\text{BMD}}_{15\text{CD}}$ and the ${\text{BMDL}}_{15\text{CD}}$, and below the ${\text{BMDL}}_{15\text{CD}}$, respectively.