Table 1.

Sampled exposure space parameters.

Route of exposure	D (units)	$\mathrm{\tau }$ (h)	$\mathrm{\Delta }$ (h)
Oral	$1\times {10}^{-5}-10\hspace{0.17em}\left(\mathrm{mg}/\mathrm{kg}\right)$	4–24	$0.001-\mathrm{\tau }$
Dermal	$1\times {10}^{-4}-100\hspace{0.17em}\left(\mathrm{mg}/\mathrm{kg}\right)$	4–24	$0.1-\mathrm{\tau }$
Inhalation	$1\times {10}^{-5}-10\hspace{0.17em}\left({\mathrm{mg}/\mathrm{m}}^3\right)$	4–24	$0.05-\mathrm{\tau }$

Note: Parameters comprising the exposure space database (ESD) were sampled from a uniform distribution where D is the administered dose, $\mathrm{\tau }$ represents the time between dosing events, and $\mathrm{\Delta }$ represents the duration of exposure. Here, the periodicity ($\mathrm{\tau }$) represents the amount of time (in hours) between the start of each dosing event, and the duration ($\mathrm{\Delta }$) represents how long the dosing event lasted.