Table 3.

Comparison of benchmark doses for various points of departure.

End point	Peak brain CPF concentration
	BMD ($\mathrm{\mu }\mathrm{M}$)	BMDL ($\mathrm{\mu }\mathrm{M}$)
15% Cognitive deficit	$1.23\times {10}^{-4}$	$8.82\times {10}^{-6}$
20% RBC AChE inhibition	$1.91\times {10}^{-4}$	$1.73\times {10}^{-4}$
10% Brain AChE inhibition	$6.11\times {10}^{-4}$	$4.83\times {10}^{-4}$

Note: Twenty percent RBC AChE inhibition and 10% brain AChE inhibition were determined by Reiss et al. (2012). Peak brain chlorpyrifos (CPF) concentrations were determined from the human exposure space database for all three end points. AChE, acetylcholinesterase; BMD, predicted benchmark dose corresponding to each end point; BMDL, lower limit benchmark dose corresponding to each end point; RBC, red blood cells.