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. 2018 Jun 8;59(8):1341–1366. doi: 10.1194/jlr.R085324

TABLE 2.

Phospho-regulation of mammalian LTPs

Human LTP Phospho-Regulation References
CERT (GPBPΔ26, STARD11) Hyper-phosphorylation of the SRM inhibits the activities of the PH and START domains of CERT (see also the text) (7375)
Phosphorylation of Ser315 enhances the affinity of CERT for VAP (see also the text) (72)
StAR (STARD1) Phosphorylation of Ser195 (Ser194 in the mouse) by protein kinase A upregulates its steroidogenic function (227, 228)
Phosphorylation of Ser232 by ERK1 may modulate StAR (229)
OSBP Multisite phosphorylation of OSBP regulates sterol enclosing (230)
PCTP (STARD2) Phosphorylation of Ser110 (possibly by protein kinase C) induces its mitochondrial relocation (231)
PITPβ (PI/SM-TP) Phosphorylation of Ser262 (possibly by protein kinase C) induces its Golgi relocation (232)
STARD10 Phosphorylation of Ser284 by casein kinase 2 reduces its affinity to membranes and down-regulates its PC/PE transfer activity (233)
ORP3 Hyper-phosphorylation of ORP3 enhances its affinity for VAP (234)

Alternative names of LTPs are indicated in parentheses. PCTP, PC-transfer protein; PITPβ, PITP β isoform; PI/SM-TP, PI/SM-transfer protein.