TABLE 2.
Human LTP | Phospho-Regulation | References |
CERT (GPBPΔ26, STARD11) | Hyper-phosphorylation of the SRM inhibits the activities of the PH and START domains of CERT (see also the text) | (73–75) |
Phosphorylation of Ser315 enhances the affinity of CERT for VAP (see also the text) | (72) | |
StAR (STARD1) | Phosphorylation of Ser195 (Ser194 in the mouse) by protein kinase A upregulates its steroidogenic function | (227, 228) |
Phosphorylation of Ser232 by ERK1 may modulate StAR | (229) | |
OSBP | Multisite phosphorylation of OSBP regulates sterol enclosing | (230) |
PCTP (STARD2) | Phosphorylation of Ser110 (possibly by protein kinase C) induces its mitochondrial relocation | (231) |
PITPβ (PI/SM-TP) | Phosphorylation of Ser262 (possibly by protein kinase C) induces its Golgi relocation | (232) |
STARD10 | Phosphorylation of Ser284 by casein kinase 2 reduces its affinity to membranes and down-regulates its PC/PE transfer activity | (233) |
ORP3 | Hyper-phosphorylation of ORP3 enhances its affinity for VAP | (234) |
Alternative names of LTPs are indicated in parentheses. PCTP, PC-transfer protein; PITPβ, PITP β isoform; PI/SM-TP, PI/SM-transfer protein.