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. 2018 Jun 26;59(8):1414–1423. doi: 10.1194/jlr.M084442

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Copyright © 2018 Ban et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 1. — Aged (12 months) Abca1/g1⁻^rod/⁻^rod mouse retinas show decreased scotopic responses and accumulation of lipids. A–C: ERG of 3-month-old Abca1/g1^F/F and Abca1/g1⁻^rod/⁻^rod mice. Abca1/g1^F/F (blue circles), n = 7; Abca1/g1⁻^rod/⁻^rod (red squares), n = 5. A: Scotopic a-wave amplitude. B: Scotopic b-wave amplitude. C: Photopic b-wave amplitude. No significant difference was detected by two-way ANOVA. D–F: ERG of 12-month-old Abca1/g1^F/F and Abca1/g1⁻^rod/⁻^rod mice. Abca1/g1^F/F (blue squares), n = 5; Abca1/g1⁻^rod/⁻^rod (red squares), n = 5. D: Scotopic a-wave amplitude. E: Scotopic b-wave amplitude. F: Photopic b-wave amplitude. **P < 0.01 and ***P < 0.001 by two-way ANOVA with post hoc Bonferroni’s multiple comparison test. G: Representative fundus images of 12-month-old Abca1/g1^F/F and Abca1/g1⁻^rod/⁻^rod mouse retinas. H, I: Representative electron microscopy images of 12-month-old Abca1/g1^F/F and Abca1/g1⁻^rod/⁻^rod mouse retinas. Scale bar: 1 μm. H: Attenuation of vesicular structures at the rod inner and outer segment in Abca1/g1⁻^rod/⁻^rod mouse retinas. I: Dysmorphic change of outer segments of Abca1/g1⁻^rod/⁻^rod mouse retinas (dashed circle). J: Accumulation of large lipid droplets within the RPE (red arrowheads). Values are mean ± SE.