Lipid mediators and lipid-related proteins carried by extracellular vesicles. AA, arachidonic acid; 12-HETE, 12-hydroxyeicosatetraenoic acid; LTB4, leukotriene B4; LTC4, leukotriene C4; PGE2 and 15d-PGJ2, prostaglandins; Cer, ceramide; S1P, sphingosine 1 phosphate; PA, phosphatidic acid; LPA, lyso-phosphatidic acid; LPC, lyso phosphatidylcholine; AEA, N-arachidonoylethanolamine (endocannabinoid). For graphical simplification, lipid-related proteins are plotted inside the vesicle; localization for some of them in the membrane of a native extracellular vesicle cannot be excluded.