Table 2. In vitro toxicity of tacrine–neocryptolepines 1–3 and reference compound tacrine in HepG2 cells.
Comp | 1 μM | 10 μM | 100 μM | 300 μM |
1 | 99.5 ± 0.7ns | 37.2 ± 3.4*** | 33.8 ± 3.0*** | 34.8 ± 2.9*** |
2 | 40.9 ± 0.9*** | 34.9 ± 4.5*** | 36.2 ± 3.7*** | 36.5 ± 4.0*** |
3 | 78.1 ± 2.3* | 41.4 ± 4.6*** | 38.4 ± 3.3*** | 37.9 ± 1.9*** |
Tacrine | 93.4 ± 4.7ns | 88.7 ± 3.4ns | 64.3 ± 4.5*** | 40.0 ± 2.2*** |