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. 2017 Apr 28;8(6):1307–1317. doi: 10.1039/c7md00143f

Table 2. In vitro toxicity of tacrine–neocryptolepines 1–3 and reference compound tacrine in HepG2 cells.

Comp 1 μM 10 μM 100 μM 300 μM
1 99.5 ± 0.7ns 37.2 ± 3.4*** 33.8 ± 3.0*** 34.8 ± 2.9***
2 40.9 ± 0.9*** 34.9 ± 4.5*** 36.2 ± 3.7*** 36.5 ± 4.0***
3 78.1 ± 2.3* 41.4 ± 4.6*** 38.4 ± 3.3*** 37.9 ± 1.9***
Tacrine 93.4 ± 4.7ns 88.7 ± 3.4ns 64.3 ± 4.5*** 40.0 ± 2.2***