Fig. 7. Interactions of compound 11i. In the illustration, tubulin α (orange) and β (cyan) subunits were represented. Trimethoxyphenyl group is in contact with residues Cysβ241 and Valβ238. Moreover, two hydrogen bonds were observed between the amide group in position 3 and Asnα101 as well as between the ketone oxygen of the scaffold and Aspβ251. This interaction pattern was common to compounds 11i and 2b.
