Table 3.
Between-day variability – descriptive statistics of the non-transformed biomarker concentrations () for the within-woman daily pooled samples from subgroup 1 and subgroup 2 (8 women, daily pools, one daily pool for each day of the first week of collection), and ICCs based on phenol biomarker concentrations, creatinine concentration, and specific gravity. Values were not standardized for creatinine or specific gravity.
Biomarker | LOD () | Results above the LOD, (%) | Percentiles | Between-day ICC (95% CI)a | ||||
---|---|---|---|---|---|---|---|---|
5th | 25th | 50th | 75th | 95th | ||||
Phenols ()b | ||||||||
2,4-Dichlorophenol | 0.1 | 56 (100) | 0.1 | 0.2 | 0.3 | 0.4 | 6.0 | 0.91 (0.82, 1.00) |
2,5-Dichlorophenol | 0.1 | 56 (100) | 0.2 | 0.3 | 0.8 | 3.6 | 269.6 | 0.98 (0.95, 1.00) |
Butyl paraben | 0.1 | 45 (80) | 0.1 | 0.1 | 0.2 | 1.1 | 35.2 | 0.80 (0.61, 0.99) |
Ethyl paraben | 1.0 | 39 (70) | 2.8 | 12.9 | 45.5 | 0.85 (0.70, 1.00) | ||
Methyl paraben | 1.0 | 56 (100) | 2.4 | 9.2 | 33.0 | 89.7 | 1350.8 | 0.84 (0.69, 1.00) |
Propyl paraben | 0.1 | 56 (100) | 0.1 | 0.4 | 2.2 | 39.9 | 161.8 | 0.90 (0.80, 1.00) |
Benzophenone-3 | 0.2 | 28 (50) | 0.5 | 3.1 | 33.8 | 0.73 (0.50, 0.96) | ||
Bisphenol A | 0.1 | 56 (100) | 0.4 | 1.0 | 1.9 | 3.5 | 8.2 | 0.60 (0.30, 0.89) |
Bisphenol S | 0.1 | 56 (100) | 0.1 | 0.2 | 0.2 | 0.4 | 2.8 | 0.14 (0.00, 0.39) |
Triclosan | 1.0 | 45 (80) | 1.1 | 2.1 | 3.0 | 63.7 | 0.89 (0.78, 1.00) | |
Urine dilution markers | ||||||||
Creatinine (mg/dL) | NA | 56 (100) | 30.6 | 60.4 | 77.9 | 102.2 | 146.8 | 0.60 (0.30, 0.89) |
Specific gravity | NA | 56 (100) | 1.009 | 1.013 | 1.016 | 1.02 | 1.029 | 0.61 (0.32, 0.90) |
Note: CI, confidence interval; ICC, intraclass correlation coefficient; LOD, limit of detection; NA, not applicable.
ICCs were estimated from ANOVA with a random effect on woman.
Concentrations below the LOD were replaced by instrumental reading values. For each phenol biomarker, instrumental reading values equal to 0 were replaced by the lowest non-zero instrumental reading value divided by the square root of 2.