Table 5.
Alternative estimate of between-week variability based on three random spot samples – descriptive statistics of the non-transformed biomarker concentrations () for the random spot samples from subgroup 1 and subgroup 2 (8 women, random spot samples, one sample in each of the three weeks of collection), and ICCs based on phenol biomarker concentrations, creatinine concentration, and specific gravity. Values were not standardized for creatinine or specific gravity.
| Biomarker | LOD () | Results above the LOD, N (%) | Percentiles | Between-week ICC (95% CI)a | ||||
|---|---|---|---|---|---|---|---|---|
| 5th | 25th | 50th | 75th | 95th | ||||
| Phenols ()b | ||||||||
| 2,4-Dichlorophenol | 0.1 | 24 (100) | 0.1 | 0.2 | 0.4 | 0.5 | 2.2 | 0.50 (0.08, 0.92) |
| 2,5-Dichlorophenol | 0.1 | 23 (96) | 0.1 | 0.3 | 0.8 | 1.4 | 70.3 | 0.85 (0.69, 1.00) |
| Butyl paraben | 0.1 | 19 (79) | 0.1 | 0.1 | 0.1 | 3.8 | 8.0 | 0.42 (0.00, 0.87) |
| Ethyl paraben | 1.0 | 16 (67) | 2.4 | 10.5 | 21.1 | 0.40 (0.00, 0.85) | ||
| Methyl paraben | 1.0 | 24 (100) | 2.3 | 5.0 | 15.4 | 106.3 | 276.7 | 0.85 (0.68, 1.00) |
| Propyl paraben | 0.1 | 24 (100) | 0.1 | 0.5 | 4.2 | 34.5 | 99.3 | 0.70 (0.40, 1.00) |
| Benzophenone-3 | 0.2 | 13 (54) | 0.8 | 4.5 | 47.4 | 0.28 (0.00, 0.75) | ||
| Bisphenol A | 0.1 | 23 (96) | 0.1 | 0.4 | 1.1 | 2.6 | 8.0 | 0.38 (0.00, 0.83) |
| Bisphenol S | 0.1 | 22 (92) | 0.1 | 0.1 | 0.2 | 0.4 | 12.3 | 0.33 (0.00, 0.80) |
| Triclosan | 1.0 | 13 (54) | 1.1 | 2.4 | 29.9 | 0.11 (0.00, 0.58) | ||
| Urine dilution markers | ||||||||
| Creatinine (mg/dL) | NA | 24 (100) | 13.90 | 28.65 | 67.43 | 125.94 | 156.25 | 0.54 (0.14, 0.94) |
| Specific gravity | NA | 24 (100) | 1.005 | 1.007 | 1.016 | 1.021 | 1.029 | 0.69 (0.39, 1.00) |
Note: CI, confidence interval; ICC, intraclass correlation coefficient LOD, limit of detection; NA, not applicable.
ICCs were estimated from ANOVA with a random effect on woman. For triclosan analysis, an extreme value was excluded ( samples).
Concentrations below the LOD were replaced by instrumental reading values. For each phenol biomarker, instrumental reading values equal to 0 were replaced by the lowest non-zero instrumental reading value divided by the square root of 2.