Table 2.
Association of rs76895963 in CCND2 with type 2 diabetes, diabetes-related intermediate traits and anthropometric traits
| Trait/disease | Study | Effect size | 95% CI | P-value | N | I2 | Phet |
|---|---|---|---|---|---|---|---|
| Type 2 diabetes (BMI adjusted) (OR) |
Original study Current study Combined |
0.46 0.49 0.47 |
0.40, 0.54 0.40, 0.58 0.42, 0.53 |
6 × 10-23 2 × 10-14 1 × 10-35 |
12,939 vs. 70,909 6,647 vs. 12,645 19,586 vs. 83,554 |
0% 0% 0% |
0.7 0.6 0.6 |
| Type 2 diabetes (BMI unadjusted) (OR) |
Original study Current study Combined |
0.53 0.53 0.53 |
0.46, 0.61 0.45, 0.63 0.48, 0.59 |
8 × 10-19 2 × 10-13 1 × 10-30 |
12,939 vs. 70,909 6,647 vs. 12,645 19,586 vs. 83,554 |
0% 0% 0% |
0.7 0.7 0.9 |
| Fasting glucose (log) |
Original study Current study Combined |
-0.01 -0.02 -0.01 |
-0.02, -0.01 -0.02, -0.01 -0.02, -0.01 |
3 × 10-4 5 × 10-5 9 × 10-8 |
11,764 11,739 23,503 |
NA 0% 0% |
NA 0.9 0.8 |
| 2 hour OGTT (log) |
Original study Current study Combined |
-0.02 -0.05 -0.04 |
-0.04, 0.01 -0.08, -0.03 -0.05, -0.02 |
0.15 6 × 10-5 1 × 10-4 |
4,900 8,261 13,161 |
NA 0% 44% |
NA 0.6 0.2 |
| Matsuda index (log10)+ | Current study | 0.02 | 0.01, 0.03 | 5 × 10-3 | 13,118 | 0% | 0.8 |
| Disposition index (log10)+ | Current study | 0.07 | 0.05, 0.09 | 2 × 10-11 | 13,028 | 0% | 0.7 |
| Insulinogenic index (log10)+ | Current & Original study | 0.05 | 0.03, 0.07 | 8 × 10-6 | 13,181 | 0% | 0.5 |
| Fasting proinsulin (log10)* | Current study | 0.01 | -0.01, 0.02 | 0.5 | 6,985 | NA | NA |
| 30 min proinsulin (log10)* | Current study | -0.01 | -0.02, 0.01 | 0.3 | 6,947 | NA | NA |
| 120 min proinsulin (log10)* | Current study | -0.01 | -0.02, 0.00 | 0.1 | 6,978 | NA | NA |
| BMI (kg/m2) |
Population based studies** Current study *** Combined |
0.36 0.05 0.25 |
0.06, 0.65 -0.21, 0.30 0.08, 0.43 |
0.02 0.7 4 x 10-3 |
24,807 22,464 109,492 |
0% 0% 2% |
0.8 0.7 0.4 |
| Fat mass % (log10) | Current study | 0.00 | -0.01, 0.01 | 0.5 | 6,979 | NA | NA |
| Height (cm) |
Original study Current study Combined |
1.16 1.38 1.24 |
0.83, 1.50 0.92, 1.84 0.97, 1.51 |
6 × 10-12 6 × 10-9 2 × 10-19 |
78,236 13,927 92,163 |
0% 0% 0% |
0.7 0.6 0.8 |
Phet: Heterogeneity p value; NA: Not applicable because data from only one study was available.
Analysis of diabetes-related intermediate traits and height reported in the table were performed in non-diabetic individuals.
Values were adjusted for corresponding insulin measurements at same time-points during OGTT.
Results from population studies with no apparent enrichment for or against type 2 diabetes, including 3 studies from the original publication (Iranian TLGS study, Danish Inter99 study and Danish Health2006 study) and ALSPAC.
To avoid “index event bias” or “truncation bias” we used our population based studies (see method and discussion).
For Insulinogenic index we give the meta analysis results including data presented in the original paper from the Inter99 study. For Matsuda index and disposition index we give the meta analysis results including a new analysis of the Inter99 study, not previously presented.