Fig. 5. X-ray crystal structure representation of 18 co-complexed with TYK2 JH2 (PDBID 5TKD). (a) Close-up of the binding site. Hydrogen bond interactions are shown with dotted lines with key residues and observed water labelled. TYK2 JH2 ribbon and carbons in green. Carbons of 18 in magenta. (b) Surface representation of the protein binding site highlighting space off of the C3 amide and part of the C6 aniline (yellow arrows). Hydrogens added for clarity.
