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| ||||
| R2 | TYK2 JH2 (IC50, μM) | TYK2/JAK1/JAK2 JH1 (IC50, μM) | IL23/IFNα (IC50, μM) | |
| 7 |
|
0.48 | >50 | 8.6/12.6 |
| 10 |
|
0.032 | >2 | 1.1/1.5 |
| 11 |
|
0.022 | >50/>2/>50 | 0.7/1.4 |
| 12 |
|
0.024 | >2 | 1.4/1.7 |
| 13 |
|
0.22 | >2 | 3.4/3.2 |
