Table 2. Optimization of C-8 amine.
| |||
| R1 | TYK2 JH2 (IC50, μM) | IL23/IFNα (IC50, μM) | |
| 11 |
|
0.022 | 0.7/1.4 |
| 18 |
|
0.007 | 0.1/0.05 |
| 19 |
|
0.017 | 0.6/0.6 |
| 20 |
|
0.11 | 6.2/4.1 |
| 21 |
|
0.50 | 7.3/4.8 |
| 22 |
|
0.05 | 4.9/3.7 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.