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| ||||||
| R2 | R3 | TYK2 JH2 (IC50, μM) | IL23/IFNα (IC50, μM) | PDE4 (IC50, μM) | LM % rem (h/r/m) | |
| 31 |
|
|
0.013 | 0.51/0.41 | 2.4 | 41/4/3 |
| 32 |
|
|
0.004 | 0.33/0.20 | 0.38 | 51/16/0 |
| 33 |
|
|
0.066 | 1.2/1.1 | >100 | 89/86/65 |
| 34 |
|
|
0.025 | 0.41/0.32 | >33 | 96/80/50 |
| 35 |
|
|
0.008 | 0.78/0.75 | 5.6 | 75/75/34 |
