Table 6. Relationship of protein binding to whole blood potency.

	TYK2 JH2 (IC50, μM)	IL23/IFNα (IC50, μM)	% unbound (h/r/m)	hWB IFNa IP-10 (IC50, μM)
29	0.004	0.24/0.16	27/31/30	0.37
34	0.025	0.41/0.32	0.4/0.5/0.4	>10
35	0.008	0.78/0.75	1.0/1.2/1.2	4.2