Table 3.

Adjusted change in 14-year SRS-2 total T-score, and the two SRS-2 DSM-V compatible SCI and RRB T-scores, per 10-fold increase in creatinine-adjusted prenatal urinary DAPs, DEs, DMs and OP pesticide use within $1\mathrm{km}$ of residence during pregnancy using pesticide use reporting (PUR) data in the CHAMACOS study population, enrolled 1999–2000 in Salinas Valley, California.

OP pesticide exposure	$n$	SRS-2 Total T-scorea	SCI T-scorea	RRB T-scorea
		$\mathrm{\beta }$ (95% CI)	$\mathrm{\beta }$ (95% CI)	$\mathrm{\beta }$ (95% CI)
Urinary metabolites
DAPs	246	2.7 (0.9, 4.5)	2.8 (0.9, 4.6)	2.2 (0.3, 4.0)
DEs	246	1.0 ($-0.8$, 2.7)	0.8 ($-1.0$, 2.6)	1.5 ($-0.2$, 3.2)
DMs	247	2.4 (0.8, 4.0)	2.5 (0.8, 4.2)	1.7 (0.1, 3.3)
PUR data (kg within $1\mathrm{km}$)
Chlorpyrifos	235	$-0.6$ ($-1.8$, 0.7)	$-0.7$ ($-2.0$, 0.6)	$-0.1$ ($-1.4$, 1.1)
Diazinon	235	$-0.4$ ($-2.0$, 1.1)	$-0.5$ ($-2.1$, 1.1)	$-0.3$ ($-1.8$, 1.3)
Malathion	235	0.5 ($-0.7$, 1.8)	0.4 ($-0.9$, 1.6)	0.9 ($-0.3$, 2.1)
Oxydemeton-methyl	235	$-0.3$ ($-1.7$, 1.0)	$-0.5$ ($-1.9$, 0.9)	0.2 ($-1.1$, 1.5)
Total OP pesticides	235	$-0.2$ ($-1.4$, 1.0)	$-0.3$ ($-1.6$, 0.9)	0.3 ($-1.0$, 1.5)
Toxicity-weighted OP pesticidesb	235	$-0.2$ ($-1.0$, 0.7)	$-0.3$ ($-1.1$, 0.6)	0.1 ($-0.8$, 0.9)

OP, organophosphate; DAPs, dialkyl phosphates; Des, diethyl phosphates; DMs, dimethyl phosphates; SRS-2, Social Responsiveness Scale, Version 2; SCI, Social Communication and Interaction; RRB, Restricted and Repetitive Behaviors; CI, confidence interval.

Adjusted for maternal age, education, country of birth, years in the United States, language of questionnaire, parity, marital status, depression, child’s age at assessment, sex and quality of the home environment. Maternal depression score was missing for one participant, leaving 235 observations in models of associations with PUR data, 247 for total DMs, and 246 for total DEs and DAPs.

^a$\mathrm{T}-\text{score}\text{standardized}\text{mean}=50$ ($\text{SD}=10$); higher SRS score indicates more ASD-related traits.

^bOP toxicity-weighted use in kg-equivalents of chlorpyrifos.