Table 1. Minimum inhibitory concentrations (MIC) of crystallomycins 1 and 2 against Gram-positive bacteria, μg mL–1.
Microorganism | Antimicrobial
a
|
||||
Cub | 1(Ca2+) | 1 | 2(Ca2+) | 2 | |
S. aureus ATCC 29213 | 0.5 | 4 | 16 | 2 | 4–8 |
MRSA 86 | 1 | 4 | 16 | 2 | 8 |
MRSA 88 | 0.5–1 | 4 | 16 | 2 | 8 |
MRSA 71001 | 0.5–1 | 4 | 16 | 2 | 8 |
MRSA 20450 | 1 | 2 | 16 | 1–2 | 8 |
MRSA 17 | 2 | 4 | nd b | 4 | 8 |
S. epidermidis C2001 (MR) | 1 | 4 | 16 | 2 | 4–8 |
S. epidermidis 004-T1 (MR) | 1 | 4 | 32 | 4 | 16 |
S. epidermidis 20459 (MR) | 1 | 4 | nd | 4 | nd |
E. faecalis ATCC 29212 | 4 | 8 | nd | 8 | 16 |
E. gallinarum VP4147 | 8 | 4–8 | nd | 4–8 | 16 |
aCub – cubicin (daptomycin); (Ca2+) – in the presence of calcium ions (1.25 mM).
bnd – not determined.