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. 2018 Feb 27;9(4):667–675. doi: 10.1039/c8md00002f

Table 1. Minimum inhibitory concentrations (MIC) of crystallomycins 1 and 2 against Gram-positive bacteria, μg mL–1.

Microorganism Antimicrobial a
Cub 1(Ca2+) 1 2(Ca2+) 2
S. aureus ATCC 29213 0.5 4 16 2 4–8
MRSA 86 1 4 16 2 8
MRSA 88 0.5–1 4 16 2 8
MRSA 71001 0.5–1 4 16 2 8
MRSA 20450 1 2 16 1–2 8
MRSA 17 2 4 nd b 4 8
S. epidermidis C2001 (MR) 1 4 16 2 4–8
S. epidermidis 004-T1 (MR) 1 4 32 4 16
S. epidermidis 20459 (MR) 1 4 nd 4 nd
E. faecalis ATCC 29212 4 8 nd 8 16
E. gallinarum VP4147 8 4–8 nd 4–8 16

aCub – cubicin (daptomycin); (Ca2+) – in the presence of calcium ions (1.25 mM).

bnd – not determined.