Table 1.

Protocol Comparison

	Evidence-based regimen	Original FDA-approved regimen (as approved in 2000)
Dates in use in study data	January 2010–January 2011	February 2011–March 2016
Maximum days gestation	9 weeks from LMPa	7 weeks from LMP
Mifepristone dose	200 mg orally in office	600 mg orally in office
Misoprostol dose	800 mcg vaginally or buccally (four tablets)	400 mcg orally (two tablets)
Misoprostol timing	6–72 h after mifepristone	48 h after mifepristone
Misoprostol location	Home	Provider's office
Follow-up visit	5–14 days after mifepristone	14 days after mifepristone
Cost	Lower	Higherb
Minimum number of office visits (including Ohio's required information visit)	3	4
Efficacy rate	95–99% up to 9 weeks gestation	92% up to 7 weeks gestation

Adapted from Reproductive Health Access Project⁴⁴ and American College of Obstetricians and Gynecologists.⁶

^aIn 2016, the FDA approved use up to 10 weeks from LMP.

^bThe original FDA protocol is more costly because it requires three times the dose of mifepristone which is a more costly drug than misoprostol.

FDA, Food and Drug Administration; LMP, last menstrual period.