Table 1. Cytotoxicity, water solubility and partition coefficients of bromanil and amino-OEG derivatives. The reported quantities are apparent average values and standard errors from replicate determinations (N = 3) are indicated.

Entry	Compound	IC50 a [μM]	UV-vis		Aqueous solubility b		Partition coefficients
			ε [L mol–1 cm–1]	λ max [nm]	[mg L–1]	[mol L–1]	log Pcalc c	log Pexp d
1	TBBQ	>100	3069.9	309	18 ± 13	5.43 × 10–5	2.57	2.53
2	D0	11.8	18 007.4	359	220 ± 25	4.40 × 10–4	1.27	1.38
3	D1	0.8	23 553.7	363	1720 ± 90	2.28 × 10–3	0.62	0.67
4	D2	>100	24 655.2	364	>1.6 × 105	>1.33	–1.40	0.21

^aDetermined using the WST-1 assay.

^bDetermined by the shake-flask method at 25 °C and UV-vis spectrophotometric quantification.

^cPredictions from ChemDraw Molecular Networks plugin.

^dDetermined by partitioning between octan-1-ol/water at 25 °C and UV-vis spectrophotometric quantification.