Table 2. In vitro cytotoxicity (IC50 in μM) a of the ligands and corresponding cobalt complexes 1–3 determined by the MTT assay after 48 h incubation.
| IC50 (μM) |
||||||
| HeLa | A549 | MDA-MB-361 | LS-174 | K562 | MRC-5 | |
| H8qaSC | 36.5 ± 3.9 | >100 | >100 | >100 | >100 | >100 |
| H8qaTSC | 75.6 ± 5.8 | >100 | >100 | >100 | >100 | >100 |
| H8qaSeSC | 6.6 ± 1.4 | 53.1 ± 2.8 | 9.2 ± 4.4 | 14.4 ± 2.3 | 4.0 ± 0.2 | 30.3 ± 3.6 |
| 1 | 17.2 ± 1.6 | 24.9 ± 3.2 | 45.5 ± 3.4 | 32.9 ± 4.5 | 37.6 ± 0.3 | 39.5 ± 1.0 |
| 2 | 46.2 ± 3.6 | >100 | >100 | >100 | >100 | >100 |
| 3 | 33.2 ± 2.2 | >100 | 36.3 ± 0.4 | >100 | 31.3 ± 5.9 | >100 |
| CDDP | 5.2 ± 0.3 | 26.2 ± 5.4 | 14.7 ± 1.2 | 22.4 ± 7.2 | 18.6 ± 3.3 | 12.1 ± 0.9 |
aValues represent the mean ± SD from three independent experiments.