Fig. 17. Schematic overview of Thioredoxin reductase (TrxR)-mediated thioredoxin-1 (Trx-1) reduction and the mode of action of some selected inhibitors. The NADPH-dependent reduction of Trx-1, a protein overexpressed in a set of cancer tissues, is mediated by TrxR. Inhibitors of either TrxR and Trx-1 have been developed and exert an action on the activation and stabilization of HIF-1α. See text for details.
