Fig. 23. 3D-structure of HIF-1α bound to p300 (PDB: 1L3E). The C-TAD domain of HIF-1α (blue ribbon) is characterized by three short helices, wrapping around the CH1 domain of p300 (pink ribbon). CH1 adopts a triangular geometry, and encompasses three cations Zn²⁺, responsible for its structural stability. Importantly, unbounded C-TAD is not structured.