Fig. 26. α-Helix mimics as antagonists of the HIF-1α/p300 interaction. A: Structure of HIF-1α bound to p300 (PDB: 1L8C), highlighting two relevant α-helix involved in the binding of the two partner proteins and their corresponding sequences (blue: HIF-1α; pink: p300; grey: Zn atoms); B: peptidomimetic designed by Henchey (ref. 154), encompassing a hydrogen bon surrogate motive (red); C: oligoamides designed by Burslem (ref. 155) to specifically mimic helix 2 or helix 3. See text for details.