Fig. 3. Comparison of the 3D structures of the HIF-1α/HIF-β and the HIF-2α/HIF-β heterodimers bound to DNA. Dark blue: HIF-1α; light blue: HIF-2α; red: HIF-β (ARNT); orange: the DNA double helix bound to the dimeric form of HIF. These two heterodimers have very close 3D structures, since HIF-1α and HIF-2α share 80% of sequence homology. HIF-1α/HIF-β: PDB code 4ZPR; HIF-2α/HIF-β: PDB code ; 4ZPK.
