Table 2. Overview of the different histone deacetylases (HDAC classical family and Sirtuins).

	HDAC “Classical family”			Sirtuins
	Class I	Class IIa and IIB	Class IV	Class III
Name	HDAC 1, 2, 3, 8.	HDAC 4, 5, 6, 7, 9, 10.	HDAC 11	SIRT 1, 2, 3, 4, 5, 6, 7.
Localization	nucleus (mainly)	IIa: nucleus and cytoplasm IIb: cytoplasm only	Nucleus (mainly)	SIRT 1, 2: cytoplasm SIRT 3, 4, 5: mitochondria SIRT 6, 7: nucleus
Mechanism	Zn2+ dependent			NAD+ dependent
Remarks	Trichostatin A as common inhibitor			—
Reference	111	111	111	118