Table 1. IC₅₀ values for antiproliferative activities of compounds 1 and 8–22 against cancer cell lines ^a .

S. No	IC50 (μM)
	Compound	A-549	Hela	MCF-7	IMR-32
1	1	13.83 ± 0.27	14.58 ± 0.13	12.87 ± 0.71	9.43 ± 0.12
2	8	17.12 ± 0.63	12.93 ± 0.94	33.56 ± 0.1	16.59 ± 0.97
3	9	16.81 ± 0.74	9.45 ± 0.61	26.61 ± 0.8.3	17.35 ± 0.26
4	10	19.19 ± 0.15	10.72 ± 0.1	15.33 ± 0.91	13.41 ± 0.78
5	11	16.46 ± 0.2	13.36 ± 0.1	18.05 ± 0.16	15.66 ± 0.93
6	12	24.36 ± 0.92	14.14 ± 0.94	26.23 ± 0.91	12.01 ± 0.58
7	13	16.37 ± 0.49	14.09 ± 0.64	39.47 ± 0.83	11.02 ± 0.22
8	14	17.9 ± 0.65	16.41 ± 0.73	16.18 ± 0.96	20.36 ± 0.74
9	15	18.03 ± 0.49	20.59 ± 0.93	20.15 ± 0.83	16.09 ± 0.24
10	16	22.17 ± 0.54	16.49 ± 0.71	17.13 ± 0.96	18.87 ± 0.42
11	17	15.68 ± 0.33	11.68 ± 0.48	11.51 ± 0.52	10.79 ± 0.4
12	18	14.17 ± 0.67	9.75 ± 0.17	11.97 ± 0.1	9.43 ± 0.29
13	19	8.13 ± 0.73	23.57 ± 0.9	23.57 ± 0.9	11.06 ± 0.95
14	20	9.92 ± 0.98	12.61 ± 0.42	14.66 ± 0.58	10.79 ± 0.45
15	21	7.58 ± 0.11	8.25 ± 0.54	12.3 ± 0.36	8.23 ± 0.34
16	22	10.6 ± 0.31	10.48 ± 0.15	12.54 ± 0.23	11.86 ± 0.44
17	Piperine b	11.89 ± 0.18	19.21 ± 0.73	12.96 ± 0.49	10.19 ± 0.38
18	Combretastatin c	6.45 ± 0.41	5.36 ± 0.12	4.63 ± 0.47	5.72 ± 0.4

^aIC₅₀ is defined as the concentration which results in a 50% decrease in cell number compared with that of the control cultures in the absence of an inhibitor and the values were calculated using the respective regression analysis. The values represent the mean ± SE of three individual observations.

^bPiperine was employed as a positive control.

^cCombretastatin was also employed as a positive control.