Table 4. Differences at end of treatment in alpha diversity and median relative abundance of taxa between subjects who had or did not have a confirmed recurrence of C. difficile during the study.
Alpha diversity | Recurrence | No recurrence | P-value | |
n | 11 | 69 | ||
Chao | Mean | 280 | 365 | <0.05 |
Stdev* | 81.6 | 133 | ||
Shannon | Mean | 2.89 | 3.67 | <0.05 |
Stdev | 0.89 | 1.11 | ||
PD | Mean | 7.33 | 10.56 | <0.01 |
Stdev | 1.04 | 3.94 | ||
Median Relative Abundance | Recurrence | No recurrence | P-value | |
Taxa higher in subjects without recurrence | ||||
Firmicutes | 3.18E-02 | 1.11E-01 | <0.05 | |
o_Clostridiales | 1.57E-02 | 8.85E-02 | <0.05 | |
f_Lachnospiraceae | <LLD | 2.68E-03 | <0.05 | |
g_Blautia | <LLD | 1.91E-04 | <0.05 | |
f_Ruminococcaceae | <LLD | 6.70E-04 | <0.05 | |
Taxa higher in subjects with recurrence | ||||
Proteobacteria | ||||
c_Gammaproteobacteria | 5.70E-01 | 1.60E-01 | <0.05 | |
f_Enterobacteriaceae | 5.70E-01 | 1.05E-01 | <0.05 | |
g_Erwinia | 5.74E-04 | 9.57E-05 | <0.05 | |
g_Klebsiella | 7.57E-02 | 5.74E-03 | <0.05 | |
Klebsiella oxytoca | 3.11E-03 | 9.57E-05 | <0.05 | |
g_Salmonella | 5.26E-04 | <LLD | <0.01 | |
Salmonella enterica | 5.26E-04 | <LLD | <0.01 |
*Stdev = standard deviation.
PD = phylogenetic diversity.
c = class, o = order, f = family, g = genus, s = species.