Table 1. Most potent compounds acting as selective COX-2 inhibitors.
| Compound | Original number of compound in the referenced paper | Celecoxib COX-2 IC50 (μM) | COX-1 IC50 (μM) | COX-2 IC50 (μM) | Selectivity index (SI) | Analysis | Ref. |
| 2d | 14d | 0.87 | 5.6 | 0.97 | 5.77 | a | 26 |
| 3a | 15a | 0.87 | 5.9 | 0.97 | 6.08 | a | 26 |
| 4j | 10j | 0.87 | 2.14 | 0.56 | 3.82 | a | 27 |
| 6d | 4d | 0.07 ± 0.01 | 36.11 ± 0.56 | 0.08 ± 0.03 | ∼451 | b | 28 |
| 7t | 7t | 0.31 ± 0.12 | 48.20 ± 1.30 | 0.09 ± 0.01 | >500 | b | 29 |
| 9d | 8d | 0.06 | >100 | 0.02 | >5000 | c | 33 |
| 11f | 11f | 0.07 | 0.91 | 0.03 | 30.3 | d | 34 |
| 12e | 5 | — | No inhibition at 10 μM | 0.92 ± 0.05 | — | e | 36 |
| 16c | 3c | 0.02 | No inhibition in the range 10–9–10–3 M | 1.2 | — | c | 39 |
| 17i | 4i | 0.02 | >200 | 3 | >67 | a | 39 |
| 23e | 6e | 0.1 | 63.76 | 0.48 | 132.83 | e | 41 |
| 24b | 7b | 0.18 | >50 | 0.11 | >454.54 | f | 43 |
| 24c | 7c | 0.18 | >50 | 0.13 | >384.61 | f | 43 |
| 25c | 13c | 0.18 | >50 | 0.14 | >357.14 | f | 43 |
| 25e | 13e | 0.18 | >50 | 0.13 | >384.62 | f | 43 |
| 26d | 9d | — | 34.5 | 0.063 | 547.6 | f | 44 |
| 37b | 7b | — | 10.46 | 0.09 | 116.2 | f | 48 |