Table 2. Inhibitory potency against FAAH.
| ||
| Compound | R | Inhibition of FAAH IC50 a (μM) |
| 17 | H | 0.11 |
| 26 | 5-F | 0.13 |
| 27 | 5-Cl | 0.41 |
| 28 | 5-CH3 | 0.70 |
| 29 | 5-OCH3 | 0.36 |
| 30 | 5-CN | 0.97 |
| 31 | 4-F | 0.11 |
| 32 | 6-F | 0.046 |
| 33 | 7-F | 0.052 |
| 34 | 0.41 | |
| 38 | 0.18 | |
aValues are the means of at least two independent determinations, errors are within ±20%.