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. 2017 Jan 30;8(3):616–620. doi: 10.1039/c6md00683c

Table 4. Inhibitory potency against FAAH and stability in biological environments.

Inline graphic
Compound Inhibition of FAAH IC50 a (μM) Stability in liver S9 fractions b (%) Stability in blood plasma c (%)
32 0.046 82 ± 1 93 ± 7
46 1.6 65 ± 5 93 ± 3

aValues are the means of at least two independent determinations, errors are within ±20%.

bPercent of parent remaining after incubation with rat liver S9 fractions for 30 min in presence of the co-factor NADPH; values are means ± standard deviations of independent determinations (n = 3).

cPercent of parent remaining after incubation with porcine blood plasma for 30 min; values are means ± standard deviations of independent determinations (n = 3).