. 2017 Jul 19;8(8):1697–1705. doi: 10.1039/c7md00296c

Table 1. CB₁ and CB₂ receptor affinity of 1,3,4- and 1,2,4-oxadiazole regioisomers 1a–c and 9a–c.


Compd	R	X	Y	K _i (hCB₂) ± SEM ^a [nM]	Displacement (hCB₁) ^b
1a		Br	F	2.9 ± 0.41 ^d	–13% ^c
1b		F	Br	6.7 ± 1.0 ^d	–5%
1c		CN	F	270 ± 32 ^d	–8%
9a		Br	F	25 ± 4.1	22% ^c
9b		F	Br	318 ± 55	–8%
9c		CN	F	219 ± 16	–1%
CP 55940				8.44 ± 0.18	9.26 ± 0.12
WIN 55212-2				8.57 ± 0.16	8.72 ± 0.24
HU 210				9.78 ± 0.04	9.55 ± 0.06

^aThe reported K_i-values are mean values of three independent experiments (n = 3).

^bDue to the low hCB₁ affinity, only the radioligand displacement at a test compound concentration of 1 μM is given as mean value of two independent experiments (n = 2).

^cMean value of four experiments (n = 4).

^dThe CB₂ affinity of lead compounds 1a–c has been recorded previously in another laboratory.11

Table 1. CB1 and CB2 receptor affinity of 1,3,4- and 1,2,4-oxadiazole regioisomers 1a–c and 9a–c.

Table 1. CB₁ and CB₂ receptor affinity of 1,3,4- and 1,2,4-oxadiazole regioisomers 1a–c and 9a–c.