Table 2. Binding affinities and brain pharmacokinetics of [CpM(CO)₃] complexes.

No.	Aβ1–42Ki (nM)	Brain uptake (% ID g–1)		Ref.
		2 min	60 min
40	—	0.25	0.11	60
42	—	0.25 a	0.21 a , c	61
	—	0.24 b	0.19 b , c	61
45	162	—	—	62
46	37	0.18	0.08	62
47	366	—	—	62
48	78	0.24	0.10	62
49	106.0	—	—	63
50	45.3	0.80	0.69	63
51	46.0	—	—	63
52	61.9	0.61	0.24	63
53	85.1	—	—	63
54	50.8	0.88	0.15	63
55	56.6	—	—	63
56	42.2, 37.0, d 64.5 e	1.21	0.06	63
57	142.6	0.50	0.18	64
58	75.8	0.36	0.19	64
59	64.1	0.26	0.11	64
60	24.0	0.37	0.14	64
61	18.8	1.06	0.39	65
62	22.8	—	—	65
63	12.4	0.70	0.17	65
64	22.3	—	—	65
65	204.1	—	—	65
66	42.0	0.69	0.31	65
67	130.6	—	—	65
68	15.1	0.54	0.10	65

^aThe brain uptake was measured in WT mice.

^bThe brain uptake was measured in 10 month-old APP/PS1 Tg mice.

^cExpressed as brain uptake determined at 30 min post-injection.

^dExpressed as IC₅₀ values (nM) for Aβ_1–40 aggregates.

^eExpressed as IC₅₀ values (nM).