Table 7. Performance estimates obtained from the double cross-validation method.

Outer fold #	Sensitivity	Specificity	Accuracy	p-value
1	1.00	1.00	1.00	0.0000001
2	0.64	0.93	0.80	0.0111700
3	1.00	0.86	0.94	0.0013510
4	1.00	0.75	0.89	0.0002533
5	0.82	1.00	0.92	0.0001199
6	0.91	0.82	0.86	0.0004277
7	0.62	0.69	0.65	0.0843200
8	1.00	0.90	0.92	0.1618000
9	1.00	0.89	0.95	0.0001114
10	0.94	0.80	0.88	0.0025660
Average	0.89	0.86	0.88
Std. Dev	0.15	0.10	0.10

The performance estimates (sensitivity, specificity, accuracy) for every outer iteration and the corresponding average values are shown. A p-value from McNemar's Chi-square test was computed and p < 0.05 was considered statistically significant.