Table I.

Histone methylation markers in monocytes and macrophages in atherosclerosis.

Epigenetic mediator	Histone modification	Expression in atherosclerosis	Target genes
G9a, SUV39H1	H3K9	Decreased	IL-6, IL-12p40, MIP-1α, and MIP-1β
Set7	H3K4me1	Increased	NF-κB p65
	H3K4me3	Decreased	HOXA, FOXO, KLF4, IRF8, TNFα, IL-6, IL-18, MCP-1, MMP9, MMP2, CD36 and SR-A
	H3K27me3	Decreased	HOXA, FOXO, KLF4, IRF8 and TNF-α

SUV39H1, suppressor of variegation 3–9 homologue 1; H3K9, histone H3 at lysine 9; H3K4, histone H3 at lysine 4; H3K27, histone H3 at lysine 27; me 1/3, mono/tri-methylation; Set7, SET domain containing lysine methyltransferase 7; IL, interleukin; MIP, macrophage inflammatory protein; NF-κB, nuclear factor-κB; HOXA, homeobox A; FOXO, forkhead box O; KLF4, Kruppel like factor 4; IRF8, interferon regulatory factor 8; TNFα, tumor necrosis factor-α; MCP-1, monocyte chemoattractant protein 1; MMP, matrix metalloproteinase; CD, cluster of differentiation; SR-A, macrophage scavenger receptor 1.