Table II.
Histone methylation markers in endothelial cells in atherosclerosis.
| Epigenetic mediator | Histone modification | Expression in atherosclerosis | Target genes |
|---|---|---|---|
| G9a | H3K9m2 | Decreased | ICAM1 |
| KDM4D | H3K9m2 | Increased | ICAM1 |
| KDM7A | H3K9m2 | Increased | ICAM1 |
| PHF8 | Demethylation | Increased | E2F4 |
| MLL3 | H3K4m2, H3K4m3 | Increased | MCP-1, p65 |
| LDS1 | H3K4m2, H3K4m3 H3K9m2, H3K9m3 | Decreased | MCP-1, p65 |
| SET7 | H3K4m1 | Increased | NF-κB |
| EZH2 | Increased | KLF2 |
H3K9, histone H3 at lysine 9; H3K4, histone H3 at lysine 4; MCP-1, monocyte chemoattractant protein 1; NF-κB, nuclear factor-κB; KLF2, Kruppel like factor 2; KDM 4D/7A, lysine demethylase 4D/7A; PHF8, PHD finger protein 8; MLL3, mixed-lineage leukemia protein 3; LDS1, Loeys-Dietz syndrome 1; SET7, SET domain containing lysine methyltransferase 7; EZH2, enhancer of zeste homolog 2; ICAM1, intercellular adhesion molecule 1; E2F4, E2F transcription factor 4.