Table III.

Histone methylation markers in vascular smooth muscle cells in atherosclerosis.

Epigenetic mediator	Histone modification	Expression in atherosclerosis	Target genes
KDM3a	H3K9	Increased	AGTR1, ROCR2
Epac	H3K4m3	Increased	ICAM-1
JMJD2A	H3K9	Increased	MCP-1, IL-6
EZH2	H3K27	Increased	–
SUV39H1	H3K9m3	Decreased	TNF-α

H3K9, histone H3 at lysine 9; H3K4, histone H3 at lysine 4; H3K27, histone H3 at lysine 27; ICAM1, intercellular adhesion molecule 1; IL-, interleukin; MCP-1, monocyte chemoattractant protein 1; TNF-α, tumor necrosis factor-α; AGTR1, angiotensin II receptor type 1; ROCR2, arginine utilization regulatory protein RocR; KDM3a, lysine demethylase 3A; Epac, exchange factor directly activated by cyclic adenosine monophosphate; JMJD2A, jumonji domain-containing protein 2A; EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; SUV39H1, suppressor of variegation 3–9 homolog 1.