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. 2018 May 29;18(2):1628–1636. doi: 10.3892/mmr.2018.9099

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Relationship between miR-637 and Smad3. (A) Correlation between the expression of miR-637 and Smad3 in keloid. (B) miRDB predicted that miR-637 specifically combined with Smad3. (C) The interaction between miR-637 and the Smad3 3′-UTR was tested by luciferase reporter assays. Data are presented as mean ± SEM. **P<0.01, ^^P<0.01 as indicated. (D and E) Western blotting and qPCR showed that when miR-637 was overexpressed, the expression of Smad3 was downregulated. Data are shown as mean ± SEM. **P<0.01 vs. control group (F and G) Western blotting and qPCR showed that when miR-637 was repressed, expression of Smad3 was upregulated. Data are presented as mean ± SEM. **P<0.01 vs. control group. Smad, mothers against decapentaplegic homolog; miRNA, microRNA; qPCR, quantitative polymerase chain reaction; SEM, standard error of the mean.