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. 2018 May 29;18(2):1628–1636. doi: 10.3892/mmr.2018.9099

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — miR-637 inhibits the proliferation of HKF cells by suppressing Cyclin D1. (A) MTT assay showed that following transfection with miR-637 mimic, HKF cell proliferation was repressed. Data are presented as mean ± SEM. **P<0.01 vs. control group. (B) MTT assay of HKF cells following downregulation of miR-637. Data are presented as mean ± SEM. **P<0.01 vs. control group. (C and D) Following transfection with miR-637 mimic in HKF cells, the expression of Cyclin D1 was detected by western blotting and qPCR. Data are presented as mean ± SEM. **P<0.01 vs. control. (E and F) Following downregulation of miR-637, the expression of Cyclin D1 was detected by western blotting and qPCR. Data are presented as mean ± SEM. **P<0.01 vs. control. miRNA, microRNA; qPCR, quantitative polymerase chain reaction; SEM, standard error of the mean; HKF, human keloid fibroblast.