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TCF reporter gene was activated by cyclic tensile strain in Saos-2 cells. Reporter activity was normalized by Renilla luciferase activity and mutant TCF luciferase activity was subtracted from wild-type TCF luciferase activity. Application of 12% tensile stress induced a significant two-fold increase in TCF reporter gene activity compared with the 0% tensile stress group. **P<0.01 vs. 0% tensile stress group, n=6. TCF, T-cell factor; elongation, tensile stress.
