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. 2018 Jun 25;18(2):1909–1916. doi: 10.3892/mmr.2018.9215

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Regulatory network between miRNAs and target genes associated with colorectal neoplasms. Diamonds represent target genes, with pink diamonds representing genes associated with rectal cancer and all other genes being associated with colorectal neoplasms. Grey filled ovals represent downregulated miRNA and non-filled ovals represent upregulated miRNA in the pCR group compared with the no pCR group. miR/miRNA, microRNA; nCRT, neoadjuvant chemoradiotherapy; pCR, complete response to nCRT; no pCR, incomplete response to nCRT; MCC, mutated in colorectal cancers; CDKN1B, cyclin-dependent kinase inhibitor 1B; IFNB1, interferon β1; APC, adenomatous polyposis coli; MKI67, marker of proliferation Ki-67; IL6ST, interleukin-6 signal transducer; CHEK2, cell cycle checkpoint kinase 2; CDH7, cadherin 7; CALR, calreticulin; TGFB1, transforming growth factor β1.