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. 2018 Jun 15;18(2):2043–2051. doi: 10.3892/mmr.2018.9178

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Copyright: © Lee et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — YC-1 reduces MMP-9 expression and activity in vitro and in vivo in primary cortical neuronal cultures exposed to OGD. (A) Gelatin-dependent zymography demonstrated that 30 µM YC-1 significantly suppressed MMP-9 activity 48 h after reperfusion. In the controls and the YC-1 treated animals 48 h after reperfusion (n=6/group). (B) Immunofluorescence staining revealed that 25 µM YC-1 significantly suppressed MMP-9 protein expression levels (n=5/group). Data are expressed as the mean ± standard deviation. *P<0.05 vs. control. YC-1, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole; MMP, matrix metalloproteinase.