Figure 4.

YC-1 markedly ameliorates blood-brain barrier disruption and reduces ischemic brain infarction in mice subjected to MCAO. (A) Representative images of Evans blue extravasation in the whole brain, and quantification of Evans blue leakage in ipsilateral and contralateral hemispheres of MCAO mice following 25 mg/kg YC-1 (n=7/group). (B) Nissl-stained coronal sections obtained from representative animals which received an intravenous injection of vehicle or YC-1 (5 and 25 mg/kg) prior to ischemic onset (control, n=7; 5 mkg/kg YC-1, n=6; 25 mg/kg YC-1, n=7). Scale bar=5 mm. Data are expressed as the mean ± standard deviation. *P<0.05 vs. control. MCAO, middle cerebral artery occlusion; YC-1, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.